Final answer:
Cervical myelopathy in OI patients is typically caused by spine deformities such as kyphosis or scoliosis, resulting from weakened bones due to a genetic mutation affecting collagen production. This can lead to compression of the spinal cord in the cervical spine area.
Step-by-step explanation:
Cervical myelopathy occurs in OI patients due to the consequences of weakened bones and connective tissues resulting from the genetic mutation affecting collagen production. Collagen is essential for maintaining the strength and integrity of the bone matrix. Individuals with osteogenesis imperfecta (OI) often experience a range of symptoms due to insufficient or defective collagen, leading to fragile bones and other related issues. One possible manifestation is spine deformities, such as kyphosis or scoliosis, which can result in cervical myelopathy, a condition characterized by compression of the spinal cord in the cervical spine region.
The curvature of the spine, which is a common complication in OI patients due to repeated fractures and bone deformities, can compress the spinal cord and cause cervical myelopathy. Symptoms of myelopathy can include neck pain, stiffness, and neurological deficits like weakness or numbness in the limbs. Treatment is aimed at preserving mobility and independence while minimizing the risk of fractures and bone deformities through various supports, safe exercises, and possibly surgical interventions, such as the implantation of metal rods.