Final answer:
The statement is true; the dermis constitutes a major portion of the skin, housing key structures and fibers such as elastin and collagen.
Step-by-step explanation:
The statement that the major portion of the skin is comprised of the dermis is True. Human skin consists of two main layers: the epidermis and the dermis. The dermis is the inner and thicker layer that contains an interconnected mesh of elastin and collagenous fibers, as well as blood vessels, sweat glands, and hair follicles. It is integral to the function and structure of the skin, providing support, nourishment, and flexibility.