Final answer:
Long-term use of NSAIDs can lead to severe side effects, including gastrointestinal bleeding, kidney damage, an increased risk of heart attack and stroke, and elevated risks of colon cancer, osteoporosis, macular degeneration, and depression.
Step-by-step explanation:
The long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen can lead to a number of potential side effects. One of the most significant concerns is the increased risk of gastrointestinal ulcers and gastrointestinal bleeding. NSAID use can also contribute to kidney damage, especially in individuals over 60 years of age, those on diuretics, individuals with high blood pressure, heart disease, or existing kidney disease. Furthermore, NSAIDs are associated with an increased risk of heart attack and stroke, especially when taken in high doses or for extended periods.
Other possible long-term side effects may include an increased risk of certain cancers like colon cancer, osteoporosis, macular degeneration, and mental health conditions such as depression. People taking NSAIDs regularly should be monitored for these adverse effects and should use the lowest effective dose for the shortest possible duration to reduce risks.