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What constitutes a quality incisional biopsy?

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Final answer:

A quality incisional biopsy requires careful surgical removal of tissue, maintenance of specimen orientation, and prompt, proper handling to ensure diagnostic accuracy for conditions such as cancer.

Step-by-step explanation:

A quality incisional biopsy involves the surgical removal of a tissue specimen for a detailed analysis in a medical laboratory. The purpose is often to diagnose conditions such as cancer. The biopsy must provide an adequate sample size that accurately represents the abnormality or lesion in question. It's crucial that the tissue is handled with care to prevent any crushing or distortion, as these can affect pathological evaluation. Furthermore, the orientation of the specimen should be maintained, aiding the pathologist in determining if the margins are clear of disease.

To ensure diagnostic accuracy, the biopsy should be performed with precision, often using sharp instruments for a clean cut, which minimizes damage to the surrounding tissues and preserves the pathological architecture of the tissue specimen. Additionally, proper fixation and prompt transportation to the lab are essential to prevent degradation of the sample.

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