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Burkitt's lymphoma due to EBV will develop only in patients with what translocation which activates which oncogene?

User IsaacHerb
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Final answer:

Burkitt's lymphoma is associated with the t(8;14) translocation, which causes overexpression of the MYC oncogene, leading to the transformation of normal B cells into malignant cells.

Step-by-step explanation:

Burkitt's lymphoma due to Epstein-Barr virus (EBV) develops in patients with a specific chromosomal translocation, known as t(8;14), where the MYC oncogene is moved to a position next to the heavy-chain immunoglobulin gene on chromosome 14. This translocation leads to the overexpression of the MYC protein, which is a transcription factor. As a result, this translocation contributes to the transformation of normal B cells into cancerous cells, causing rapid and uncontrolled cell growth, characteristic of Burkitt's lymphoma.

User Ashok Shah
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