Final answer:
Pyoderma gangrenosum is frequently associated with autoimmune and inflammatory disorders such as inflammatory bowel diseases, arthritis, and hematologic disorders, as well as severe skin infections like necrotizing fasciitis.
Step-by-step explanation:
Pyoderma gangrenosum is associated with various systemic conditions. Specifically, it can frequently be a manifestation of underlying autoimmune or inflammatory disorders. These conditions include inflammatory bowel diseases like ulcerative colitis and Crohn's disease, arthritis, particularly the seronegative arthropathies, and hematologic disorders such as leukemia and monoclonal gammopathy. Moreover, pyoderma gangrenosum can also be associated with conditions that lead to skin infections such as cellulitis, erysipelas, and erythema nodosum, as well as more severe and potentially life-threatening infections like necrotizing fasciitis. Of note, community-acquired and hospital-acquired staphylococcal infections, and group A streptococci (GAS), S. pyogenes, are responsible for some cases.