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What conditions cause thyrotoxicosis (inc temp, inc HR, heat intolerance) with reduced radioactive iodine uptake?

User Yvanscher
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Final answer:

Thyrotoxicosis with increased temperature, heat intolerance, and increased heart rate, in combination with reduced radioactive iodine uptake, can be caused by thyroid inflammation, exogenous thyroid hormone intake, struma ovarii, or iodine-induced hyperthyroidism such as Jod-Basedow phenomenon.

Step-by-step explanation:

Thyrotoxicosis with conditions such as increased temperature (heat intolerance), increased heart rate (rapid and irregular heartbeat), and weight loss, with reduced radioactive iodine uptake, can be associated with several conditions. The most common is thyroid inflammation, such as subacute thyroiditis or silent thyroiditis, where the thyroid gland releases hormones that were already stored within, leading to a transient hyperthyroid phase. Another condition could be the intake of exogenous thyroid hormones, which suppresses thyroid-stimulating hormone (TSH) and reduces the gland's uptake of iodine. Additionally, struma ovarii, a teratoma of the ovary that produces thyroid hormone, can lead to thyrotoxicosis without increased iodine uptake. Finally, iodine-induced hyperthyroidism, also known as the Jod-Basedow phenomenon, occurs when a patient with a goiter or autonomously functioning thyroid nodules is exposed to a large quantity of iodine, leading to hyperthyroidism with temporarily reduced radioactive iodine uptake.

Understanding the balance between hyperthyroidism and hypothyroidism is crucial. Hyperthyroidism results from overproduction of thyroid hormones (T3 and T4), leading to increased metabolic rate and symptoms such as excessive heat production, sweating, and an increased heart rate. In contrast, hypothyroidism arises from an underproduction of these hormones, causing a low metabolic rate, weight gain, and cold sensitivity among other symptoms. Goiter, often caused by iodine deficiency, prevents the thyroid from forming enough T3 and T4; the body compensates by producing more TSH, resulting in enlargement of the thyroid gland.

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