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How do acute & chronic OD on vit A present?

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Final answer:

Acute vitamin A toxicity presents with symptoms like nausea, vomiting, headache, and blurred vision, while chronic toxicity includes dry skin, bone pain, and liver damage. Both can severely impact vision and require cessation of vitamin A intake and medical attention.

Step-by-step explanation:

Acute and chronic overconsumption of vitamin A, known as hypervitaminosis A, lead to different clinical presentations. Acute vitamin A toxicity typically occurs after ingesting a large amount of vitamin A over a short period. Symptoms include nausea, vomiting, headache, dizziness, blurred vision, and uncoordinated movements. Serious cases might present with increased intracranial pressure, potentially leading to papilledema and even coma.

On the other hand, chronic vitamin A toxicity results from the ingestion of high doses over a longer period, usually months to years. Early signs are subtle and include dry skin, cheilitis, and alopecia. As toxicity progresses, individuals may suffer from bone pain, especially in the long bones, due to hypercalcemia. Chronic toxicity can also lead to liver damage, which manifests as hepatomegaly and is potentially life-threatening due to hepatic encephalopathy and cirrhosis.

Given that vitamin A is essential for vision, particularly in the rhodopsin cycle of rod cells in the retina, both acute and chronic overdoses can severely impact visual health. Addressing hypervitaminosis A involves stopping vitamin A intake, seeking medical attention, and symptomatic management, which may include addressing any vision or liver complications that arise. Due to the severe consequences associated with vitamin A overdose, it is crucial to manage dietary and supplemental intake appropriately.

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