Final answer:
Holt-Oram (heart-hand) syndrome is a genetic disorder that affects the development of the heart and upper limbs. It is characterized by abnormalities in the bones of the hands and arms, as well as heart defects. Treatment may involve surgery and therapy.
Step-by-step explanation:
Holt-Oram (heart-hand) syndrome is a genetic disorder that affects the development of the heart and upper limbs. It is characterized by abnormalities in the bones of the hands and arms, as well as heart defects such as atrial septal defects and ventricular septal defects. These defects can lead to heart problems, including arrhythmias and heart failure. The syndrome is caused by mutations in a gene called TBX5. Inheritance of the syndrome can be autosomal dominant, meaning that one copy of the mutated gene is sufficient to cause the disorder. Treatment of Holt-Oram syndrome may involve surgery to repair the heart defects and occupational or physical therapy to address hand and arm abnormalities.