Final answer:
Job Syndrome or Autosomal Dominant Hyper IgE Syndrome involves high levels of IgE and immediate hypersensitivity reactions. It is associated with symptoms like allergies and a predisposition to parasitic infections, due to the role of IgE in the immune system.
Step-by-step explanation:
Job Syndrome or Autosomal Dominant Hyper IgE
Job Syndrome, also known as autosomal dominant hyper IgE syndrome, is a condition characterized by extremely high levels of IgE, an immunoglobulin molecule usually involved in the defense against parasites and allergic reactions. Individuals with this syndrome experience immediate hypersensitivity (type I) reactions, where IgE-mediated mast cell degranulation occurs following the crosslinking of surface IgE by an antigen. This leads to the release of vasoactive amines, causing allergy symptoms such as vasodilation, edema, rash, hay fever, and asthma.
IgE has a molecular weight of 200,000 Daltons, with normal blood levels ranging from 17-450 ng/ml. In contrast, patients with Job Syndrome have much higher levels of IgE, which can be both a diagnostic marker and a contributor to their symptoms. The syndrome can also predispose individuals to parasitic infections, as IgE levels are elevated in response to these infections. The role of IgE in the immune system is critical, as it can also trigger the release of histamine that aids in the removal of parasites.