Final answer:
Immunoglobulin pattern in Wiskott-Aldrich syndrome typically shows decreased IgM and increased IgA and IgE, with variable IgG levels. Naïve B cells primarily express IgM, while IgG plays a crucial role in the secondary immune response with its high affinity antigen-binding and ability to activate complement and perform opsonization.
Step-by-step explanation:
Wiskott-Aldrich syndrome is a rare, inherited immunodeficiency disorder characterized by eczema, low platelet count, and immune dysfunction. Patients with Wiskott-Aldrich syndrome present an altered pattern of immunoglobulins, which include antibodies of various classes such as IgM, IgG, IgA, IgE, and IgD. In this condition, there is often a decrease in the levels of IgM and an increased level of IgA and IgE. IgG levels can vary, and they may be normal or low.
When discussing naïve B cells, these are typically of the IgM class and, less commonly, of the IgD class. IgM antibodies, which account for about ten percent of all antibodies, can form pentamers linked by a joining chain and can bind up to ten identical antigens. However, these are not as stable in their antigen binding as IgG antibodies, which are secreted in large quantities upon re-exposure to the same pathogen. In contrast, IgG antibodies have higher affinity and are crucial in creating a strong secondary immune response. They have two Fab sites for binding antigens and an Fc portion that participates in immune functions such as complement activation and opsonization.