Final answer:
When holding short of the active runway, the Control Tower, more precisely local control, is responsible for issuing takeoff clearances for specific runways.
Step-by-step explanation:
When holding short of the active runway, you can expect a clearance for takeoff from a specific runway by the Control Tower, specifically the local control (sometimes referred to as 'tower control'). This ATC facility is responsible for the management of all the active runways and taxiways at an airport, and it ensures that each aircraft operates safely on and in the vicinity of the airport. The local controller will give you clearance when they have determined it is safe for you to enter the runway and take off, considering other traffic on the ground and in the air.