Final answer:
Antibiotics are associated with C. difficile colitis, which can cause an overgrowth of C. difficile in the gut. Treatment often includes stopping the use of antibiotics, following up with metronidazole, and potentially a fecal transplant to restore gut flora.
Step-by-step explanation:
The drug associated with C. difficile colitis is antibiotics. The onset of this condition is often after the eradication of the normal gut microbiota by these drugs. When the balance of the normal microbiota is disrupted, Clostridium difficile, which can be a commensal bacterium, overgrows and leads to antibiotic-associated diarrhea.
For treatment, the first step is to cease the use of antibiotics. Then, if necessary, metronidazole is usually administered. In cases where metronidazole is ineffective or inappropriate, vancomycin may be used. Additionally, a fecal transplant is another treatment method, aiming to restore the balance of the gut microbiota.