Final answer:
The prefix epi- means 'on', 'over', or 'close to', indicating a position on top of or over something else, such as in 'epidermis'. It is most closely related to e. 'hypo-', meaning 'under' or 'below', even though 'hypo-' signifies the opposite position.
Step-by-step explanation:
The prefix epi- often means 'on', 'over', or 'close to'. It does not have the same meaning as the prefixes listed in the options. For example, when we talk about epidermis, it refers to the outer layer of the skin, indicating its position 'on' or 'over' the other layers. The prefix hypo-, which is among the options, means 'under' or 'below', and is closely related to 'epi-' in terms of describing positional relationships, though it conveys the opposite meaning.