Final answer:
The preferred hydraulic fluid contamination analysis equipment typically includes a Standard HPLC system and an LC-MS/MS method for detailed analysis of novel chemical entities in pharmaceutical research.
Step-by-step explanation:
The preferred hydraulic fluid contamination analysis equipment for detecting and quantifying the level of contamination in hydraulic fluid often includes the use of a Standard HPLC (High Performance Liquid Chromatography) system with a C-18 reverse phase HPLC column. For samples requiring analysis with low limits of quantification, a Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) method might be employed. When analyzing novel chemical entities (NCEs), LC-MS/MS can be used in tandem with techniques such as equilibrium dialysis and ultrafiltration to measure drug binding to plasma proteins, thus providing robust pharmacokinetic parameters. Additionally, accurate measurement typically requires sample preparation, which might include protein precipitation with acetonitrile, followed by centrifugation.