Question

________ is a skeletal disease that is characterized by low BMD and changes in the microarchitecture of bone that increase susceptibility to fracture

Answer 1

Osteoporosis is a skeletal disease characterized by weak and brittle bones due to low bone mineral density, leading to a higher risk of fractures, especially in the elderly.

Step-by-step explanation:

The skeletal disease characterized by low Bone Mineral Density (BMD) and changes in the microarchitecture of bone that increase susceptibility to fracture is known as osteoporosis. This disorder is typically associated with aging and involves an imbalance between bone formation and resorption in bone remodeling, leading to brittle and weakened bones. Bones may become so weak that fractures can occur with minimal stress or even spontaneously. Osteoporosis is a common cause of broken bones in the elderly, and it is distinct from other skeletal diseases such as Paget's disease, which involves haphazard new bone formation without the elevated blood levels of alkaline phosphatase found in Paget's.

Answer 2

Osteoporosis is a skeletal disease where decreased bone mass and altered microarchitecture lead to brittle bones and increased fracture risk, especially in the elderly.

Step-by-step explanation:

Osteoporosis is a skeletal disease characterized by low Bone Mineral Density (BMD) and changes in the microarchitecture of bone tissue, leading to increased susceptibility to fractures. This age-related disorder is marked by a decrease in bone mass, due to an imbalance between bone formation and bone resorption. As bones lose essential minerals like calcium and magnesium, they become brittle and are prone to break more easily, typically in older adults. Osteoporosis is particularly concerning because bones may weaken to a point where fractures can occur with minimal stress or even spontaneously. It is the most common cause of broken bones in the elderly, illustrating the critical importance of maintaining bone health throughout life.