Question

INH, used to treat and prevent TB, do not give with ___, can cause ____toxicity,

monitor LFT's, give ___ along with, hypotension will occur initially, then resolve

Answer 1

Isoniazid (INH) for TB treatment should avoid co-administration with hepatic enzyme inducers to prevent increased risk of hepatotoxicity. Regular LFTs and supplementation with pyridoxine (vitamin B6) are recommended to evade neurotoxicity. Initial hypotension from INH treatment typically resolves without intervention.

Step-by-step explanation:

Isonicotinic acid hydrazide (INH), used to treat and prevent tuberculosis (TB), should not be given with potent hepatic enzyme inducers, as it can increase the risk of hepatotoxicity. Therefore, it is important to monitor liver function tests (LFT's) regularly when a patient is on INH. To prevent neurotoxic effects, due to INH's structural resemblance with vitamin B6 which can lead to convulsions in infants, it is recommended to give pyridoxine (vitamin B6) along with INH treatment. Though hypotension may occur initially, this side effect typically resolves on its own over time. As INH can cause an inhibition of the 6-aminolevulinic acid synthase, it is also crucial to be mindful of conditions such as porphyrias where this drug could exacerbate the disease.