Final answer:
INH can cause peripheral neuropathy and is hepatotoxic; taking Vitamin B6 is recommended to prevent this neuropathy.
Step-by-step explanation:
Isonicotinic acid hydrazide (INH), commonly used in the treatment of tuberculosis, can cause peripheral neuropathy and is also hepatotoxic. To prevent peripheral neuropathy, it is recommended to take Vitamin B6 (pyridoxine). INH is an inhibitor of the enzyme 6-aminolevulinic acid synthase, which can lead to its adverse effects. The liver damage (hepatotoxicity) due to INH use is a significant concern and must be monitored during treatment. Hepatic porphyrias are a group of diseases where there are defects in porphyrin synthesis, but INH specifically affects Vitamin B6 levels, thus leading to neurological symptoms. Supplementing with Vitamin B6 can mitigate some of these adverse effects.