Final answer:
Newborns and premature infants are particularly susceptible to the harmful effects of ototoxic and nephrotoxic medications and are therefore either not given these medications or given them with great caution.
Step-by-step explanation:
Ototoxic and nephrotoxic medications are known to cause harm to the ears and kidneys, respectively. Given the delicate condition of their developing systems, newborns and premature infants are particularly susceptible to the adverse effects of these medications. Hence, such medications are either not administered to them or used with significant caution. It is important for healthcare providers to consider the increased risks in this age group when deciding on medication regimens.