Final answer:
Cisatracurium degrades via Hofmann elimination, with a Tmax of 3 to 5 minutes and a recovery time of 35 to 45 minutes to reach a train-of-four ratio of 0.9 after an intubating dose.
Step-by-step explanation:
Cisatracurium (brand name Nimbex) is a neuromuscular-blocking drug often used during anesthesia for surgery to relax skeletal muscles. This medication degrades through a process called Hofmann elimination, which occurs at a normal physiological pH and temperature, independently of renal or hepatic function. The Tmax, or the time to reach maximum concentration in the blood after administration, is generally around 3 to 5 minutes after a single bolus intravenous injection. Recovery time from the neuromuscular blockade produced by Cisatracurium depends on the dose administered, but the approximate time for spontaneous recovery to a train-of-four ratio of 0.9 is usually 35 to 45 minutes after the administration of an intubating dose.