Final answer:
An irreversible indirect-acting cholinergic agonist is a type of drug that inactivates the enzyme acetylcholinesterase, preventing the breakdown of acetylcholine and causing muscarinic and nicotinic effects. They have a long-lasting effect. Examples include organophosphates like sarin gas.
Step-by-step explanation:
An irreversible indirect-acting cholinergic agonist is a type of drug that inactivates the enzyme acetylcholinesterase, preventing the breakdown of the neurotransmitter acetylcholine in the synapses and causing muscarinic and nicotinic effects. These drugs have a long-lasting effect because they permanently bind to the enzyme. Examples of irreversible indirect-acting cholinergic agonists include organophosphates like sarin gas and certain pesticides.