Final Answer:
False. V(D)J rearrangement primarily occurs in the early stages of B and T cell development in the bone marrow and thymus, respectively, and not in germinal centers.
Step-by-step explanation:
VDJ rearrangement is a critical genetic process that occurs during the development of B and T cells, leading to the generation of a diverse repertoire of immunoglobulins and T cell receptors. This process involves the rearrangement of gene segments (V, D, and J) to create unique combinations, providing specificity to the immune response. VDJ rearrangement takes place primarily in the early stages of B cell development within the bone marrow and T cell development in the thymus, before the cells encounter antigens. Germinal centers, on the other hand, are specialized microenvironments within lymph nodes where mature B cells underg
Option:
The correct option is False.