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Aspirin is a __________________ of platelet clotting function.

A. Competitive agonist
B. Competitive antagonist
C. Noncompetitive agonist
D. Noncompetitive antagonist

1 Answer

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Final answer:

Aspirin is a noncompetitive antagonist of platelet clotting function since it inactivates the COX enzymes responsible for thromboxane synthesis, leading to reduced platelet aggregation.

Step-by-step explanation:

Aspirin is commonly known as a non-steroidal anti-inflammatory drug (NSAID) that has multiple roles, including reducing inflammation, pain relief, and acting as an anticoagulant. When it comes to platelet clotting function, aspirin works by inactivating cyclooxygenase enzymes (COX-1 and COX-2), which are crucial for the synthesis of thromboxanes, compounds that are involved in the formation of blood clots. Specifically, aspirin acetylates a serine residue on these enzymes, which leads to irreversible inhibition and therefore a reduction in platelet aggregation. Consequently, aspirin is characterized as a noncompetitive antagonist of platelet clotting function because it does not bind at the active site of the COX enzymes but modifies them in a way that prevents their normal functioning.

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