Final answer:
If the liver and kidneys aren't functioning correctly, drug metabolism and elimination can be affected.
Step-by-step explanation:
If the liver and kidneys aren't functioning correctly, the ability of the body to metabolize or eliminate a drug can be affected. The liver is responsible for drug metabolism, breaking down or modifying drugs into less harmful forms before excretion. The kidneys play a role in excretion of drugs, as water-soluble drugs may be excreted in the urine through processes like glomerular filtration, tubular secretion, or tubular reabsorption.