Final answer:
Amazon VPC Peering is the service that offers communication between multiple VPCs with minimal configuration and low administrative overhead.
Step-by-step explanation:
The service that allows communications between multiple VPC's with the least amount of configuration and admin overhead is Amazon VPC Peering. Amazon VPC Peering is a networking connection between two Virtual Private Clouds (VPCs) that enables you to route traffic between them using private IPv4 or IPv6 addresses. This service simplifies the network architecture, as it does not require you to set up a VPN, a dedicated hardware, or use the public internet to communicate between VPCs. Additionally, it allows for more direct network routing between VPCs compared to using a gateway or a private connection.