Final answer:
In serum sickness, a type III hypersensitivity reaction, the immunoglobulins involved are primarily IgG and IgM, which form complexes with antigens leading to inflammatory responses in various organ systems.
Step-by-step explanation:
The type of immunoglobulins triggered in serum sickness, which is a systemic type III hypersensitivity reaction, primarily involves IgG, IgM, and sometimes IgA. These antibodies can form immune complexes with antigens, leading to tissue deposition and subsequent inflammation. Serum sickness can occur due to non-self proteins from animal-derived antibodies, certain drugs, or persistent microbial antigens during chronic infections, resulting in a systemic inflammatory response. The deposition of immune complexes typically happens in various organ systems, such as the kidneys and joints, causing tissue damage.