Answer:
Hurler syndrome (MPS 1H) is the most severe subtype of mucopolysaccharidosis Type 1. This is True statement.
Step-by-step explanation:
The given statement "Hurler syndrome (MPS 1H) is the most severe subtype of mucopolysaccharidosis Type 1" is True because Hurler syndrome (MPS 1H) is indeed the most severe subtype of mucopolysaccharidosis Type 1 (MPS I). MPS I is a rare inherited metabolic disorder characterized by the deficiency of the enzyme alpha-L-iduronidase, leading to the accumulation of certain complex carbohydrates in cells.
Among the different subtypes of MPS I, Hurler syndrome stands out as the most severe form, presenting with early and progressive symptoms affecting various organ systems. Individuals with Hurler syndrome often experience developmental delays, skeletal abnormalities, organ enlargement, and a shortened lifespan if not treated promptly.
Early intervention, such as enzyme replacement therapy and hematopoietic stem cell transplantation, can mitigate the progression of symptoms and improve outcomes for individuals with Hurler syndrome. However, the severity of the condition necessitates early diagnosis and comprehensive medical management.