Question

Which cardiac abnormality is seen in Noonans syndrom

Answer 1

The cardiac abnormality seen in Noonan syndrome is hypertrophic cardiomyopathy, which occurs due to a mutation in PTPN11 that affects the endocardial cells in the heart.

Step-by-step explanation:

The cardiac abnormality seen in Noonan syndrome is hypertrophic cardiomyopathy, which is the pathological enlargement of the heart. In Noonan syndrome, this cardiac abnormality occurs due to a mutation called PTPN11, which leads to abnormal cell communication. This mutation affects the endocardial cells in the heart, not the myocardial cells as previously assumed.