Final answer:
In CPR, team leaders should have the chest compressors switch every two minutes to sustain the effectiveness of compressions and reduce fatigue.
Step-by-step explanation:
As a team leader in a scenario involving cardiopulmonary resuscitation (CPR), you should instruct the chest compressors to switch approximately every two minutes, or after about 5 cycles of 30 compressions and 2 breaths if using the 30:2 compression to ventilation ratio and no advanced airway is in place. The switch is recommended to maintain the effectiveness of the compressions, as it can be physically demanding and the quality of chest compressions can diminish quickly due to fatigue. It is important that the switch is made swiftly to minimize interruptions in chest compressions.