Question

What is the relationship between chromosomal instability and cell proliferation characteristic of tumorigenesis? (Select two that apply.)

A. The higher the frequency of cell division, the smaller the chance for genomic instability because of activation of DNA repair.
B. There is no relationship between chromosomal instability and cell proliferation rate.
C. The greater the chromosomal instability, the higher the probability of increased cell proliferation due to driver mutations.
D. The greater the chromosomal instability, the higher the probability of increased cell death due to apoptosis.
E. The higher the frequency of cell division, the greater the chance for genomic instability because of more opportunities to create mutations.

Answer 1

Chromosomal instability is related to increased cell proliferation in tumorigenesis due to driver mutations and increased opportunities for mutations. Options C and E are correct.

Step-by-step explanation:

Chromosomal instability refers to the abnormal number or structure of chromosomes in a cell. Cell proliferation, on the other hand, refers to the process of cell division and reproduction. There is a relationship between chromosomal instability and cell proliferation characteristic of tumorigenesis.

Option C: The greater the chromosomal instability, the higher the probability of increased cell proliferation due to driver mutations. Mutations can activate oncogenes that promote cell growth and division.

Option E: The higher the frequency of cell division, the greater the chance for genomic instability because of more opportunities to create mutations. Increased cell proliferation can lead to more chances of errors in DNA replication and higher genomic instability.