Final answer:
Dopamine-blocking drugs are less effective at treating the negative symptoms of schizophrenia like toneless voices or expressionless faces, despite their efficacy in managing positive symptoms like hallucinations.
Step-by-step explanation:
Regarding the treatment of schizophrenia, dopamine-blocking drugs have little effect on persistent negative symptoms such as toneless voices or expressionless faces. These symptoms are characterized by a flattened emotional state, lack of pleasure, or a decrease in basic drives. While antipsychotic medications target overactive dopamine neurotransmission and can be effective at managing certain symptoms of schizophrenia, often referred to as 'positive symptoms' like delusions and hallucinations, they are less effective at treating negative symptoms. The development and treatment of schizophrenia involve understanding the functions of neurochemicals like dopamine and glutamate within the brain.