Final answer:
The Treaty of Fort Wayne in 1809 resulted in the significant transfer of Native American lands to the United States, fueling tensions that led to further conflict between indigenous peoples and American settlers. The correct answer is option C).
Step-by-step explanation:
In 1809, the Treaty of Fort Wayne was negotiated by Indiana Governor William Henry Harrison and representatives of the Miami Tribe among other indigenous groups. A significant outcome of this treaty was C) the cession of substantial Native American lands to the United States. Indiana Governor William Henry Harrison successfully negotiated the acquisition of millions of acres of land that were otherwise controlled by Native Americans, primarily those of the Miami, Delaware, Potawatomi, and Eel River tribes. This resulted not only in a substantial loss of territory for the indigenous peoples but also added to the growing tensions between different Native American groups, some of whom did not agree on the legitimacy of the sale. It ultimately contributed to the build-up of hostilities that precipitated the conflict known as Tecumseh's War and the later Battle of Tippecanoe.