Question

Please select all answers that are TRUE:

O FA synthesis produces ATP
O ACC is activated by citrate
O ACC is inhibited by citrate
O Palmitate is the end product of FA synthesis
O All of the enzyme activities required for FA synthesis in mammals are contained in a single polypeptide chain
O The condensation reaction in FA synthesis is powered by decarboxylation of malonyl CoA
O FA synthesis doesn't depend on ATP

Answer 1

ACC is activated by citrate, palmitate is the end product of FA synthesis, and all enzymes for FA synthesis in mammals are part of a single polypeptide chain; these statements are true regarding fatty acid synthesis.

Step-by-step explanation:

The true statements concerning fatty acid (FA) synthesis are:

• ACC is activated by citrate
• Palmitate is the end product of FA synthesis
• All of the enzyme activities required for FA synthesis in mammals are contained in a single polypeptide chain
• The condensation reaction in FA synthesis is powered by decarboxylation of malonyl CoA

Acetyl-CoA carboxylase (ACC) is a regulated enzyme responsible for the synthesis of malonyl-CoA, which is a crucial step in fatty acid synthesis, and it is activated allosterically by citrate. Palmitate is indeed the end product of FA synthesis in the fatty acid synthase (FAS) complex, after a cycle of reactions that extends the fatty acid chain two carbons at a time. Moreover, in eukaryotes, all the enzymatic activities necessary for the elongation process of FA synthesis are contained within a multifunctional enzyme complex formed from a single polypeptide chain known as FAS, arranged as a dimer.