Question

Draw the pathway for the conversion of Succinyl Co A into 4 CO₂. Show the structures and names of all reactants and products, as well as the names of the enzymes. You do not need to draw the structures of ATP, NAD⁺, Co A, etc., but do show them as reactants or products in the appropriate places. You do not need to show the mechanisms of the enzymes.

Answer 1

The pathway for the conversion of Succinyl Co A into 4 CO₂ involves several steps in the citric acid cycle. Citrate is first produced and then isomerized to isocitrate. Isocitrate is then oxidized to produce alpha-ketoglutarate, NADH, and CO₂. Alpha-ketoglutarate is further decarboxylated to form succinyl CoA, NADH, and CO₂. Finally, succinyl CoA is converted to succinate, generating ATP or GTP and releasing CoA.

Step-by-step explanation:

Pathway for the Conversion of Succinyl Co A into 4 CO₂

1. The first step is the entry of acetyl-CoA into the citric acid cycle, catalyzed by citrate synthase. This produces citrate and releases CoA.
2. The second step is the isomerization of citrate to isocitrate by the enzyme aconitase.
3. In step three, isocitrate is oxidized by isocitrate dehydrogenase, yielding alpha-ketoglutarate, NADH, and CO₂.
4. In step four, alpha-ketoglutarate is decarboxylated and oxidized by alpha-ketoglutarate dehydrogenase, producing succinyl CoA, NADH, and CO₂.
5. In the final step, succinyl CoA is converted to succinate by succinyl-CoA synthetase, generating ATP or GTP and releasing CoA.
6. The cycle can then continue to regenerate oxaloacetate for the entry of another acetyl-CoA.