Final answer:
A build-up of materials from cigarette smoke inside the alveoli leads to less efficient exchange of oxygen and carbon dioxide, which in turn makes other organ systems less efficient by reducing oxygen delivery and increasing carbon dioxide in the blood.
Step-by-step explanation:
When tar and other materials from cigarette smoke build up inside the alveoli, they hinder the gas exchange process. This build-up can decrease the oxygen diffusion into the blood and increase the carbon dioxide concentration within it, as the alveoli's surface area and permeability are compromised. The decreased oxygen delivery and increased carbon dioxide result in other organ systems becoming less efficient.
The compromised gas exchange significantly affects the circulatory system, which relies on the efficient uptake of oxygen and expulsion of carbon dioxide to function properly and deliver nutrients and oxygen to cells throughout the body. If tissues do not receive enough oxygen, they cannot perform their functions adequately, leading to symptoms of fatigue, and in severe cases, organ failure.