Final answer:
Osteoblasts are the cells responsible for synthesizing the organic matrix substances in bone formation, creating the collagen component and facilitating mineralization to form strong and rigid bone structures.
Step-by-step explanation:
The cell organelles responsible for synthesizing organic matrix substances in bone formation are the osteoblasts. These cells are crucial for bone growth, repair, and remodeling. Osteoblasts develop from osteoprogenitor cells and are found in areas of the bone that are undergoing formation, such as under the periosteum and endosteum. These cells synthesize and secrete both the organic components of bone matrix, primarily collagen, and inorganic minerals. As they deposit this matrix, calcium and phosphate ions are incorporated to form hydroxyapatite, which crystallizes and provides strength and rigidity to the bone structure. Osteoblasts eventually become encased within the matrix they produce and differentiate into osteocytes, which continue to maintain the bone tissue.