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Severe pain WORSE AT NIGHT, alleviated by ASPIRIN

User Ggilberth
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Final answer:

Aspirin is effective for low-to-moderate intensity pain, particularly from inflammation, and is useful for nighttime pain relief. It's important to use aspirin and other NSAIDs carefully due to potential side effects. Specific dosage adjustment is necessary for chronic conditions such as arthritis.

Step-by-step explanation:

Aspirin, also known as acetylsalicylic acid, is a common medication that is used to treat pain, fever, and inflammation. This medication works by blocking the COX-1 and COX-2 enzymes, which are involved in the pain and inflammation process. It's been known for effectively treating pain that is low-to-moderate in intensity and is associated with inflammation, making it a common choice for relief from conditions such as arthritis. Though Aspirin and other NSAIDs like ibuprofen and naproxen are available over the counter (OTC) and can relieve numerous forms of pain, these drugs are not without potential side effects. For example, they can increase the risk of gastrointestinal ulcers and bleeds, heart attack, and kidney disease. It's important to note that when pain is chronic, such as that from long-term arthritis, the use of combination pain relievers should be under the guidance of a healthcare professional, with each medication's dosage being carefully adjusted to achieve the greatest benefit with the least side effects.

For severe pain that is worse at night and is alleviated by ASPIRIN, this indicates the pain could have inflammatory origins, as the drug doesn't change the perception of sensory modalities other than pain. If Aspirin provides relief, this suggests an inflammatory process that gets worse at night and possibly during other specific conditions such as respiratory tract infections or exposure to cold air.

User Mridul Bagla
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