Final answer:
Heavy lifting is the most relevant activity to the development of calluses.
Step-by-step explanation:
In the context of evaluating a patient with hand calluses, heavy lifting is the most relevant activity to the development of calluses.
Calluses are formed as a result of repeated friction or pressure on the skin. When heavy objects are lifted, it puts pressure on the hands and causes the skin to thicken and form calluses as a protective mechanism.
The activities of sneezing, vomiting, and coughing do not directly contribute to the development of calluses.