Final answer:
The first Sherlock Holmes story by Sir Arthur Conan Doyle is titled 'A Study in Scarlet' and was published in 1887.
Step-by-step explanation:
The first Sherlock Holmes story was titled A Study in Scarlet and was published in the 1887 Beeton's Christmas Annual. This publication marked the debut of the most famous detective in history and literature, Sherlock Holmes, who was the product of Sir Arthur Conan Doyle's imagination. Sherlock Holmes is not a real person but rather a fictional character with extraordinary deductive skills, capable of connecting disparate pieces of to solve intricate mysteries.