Final answer:
To use the Picture with Caption layout for a slide, select the Picture with Caption layout option, which is designed to display a large image with a descriptive caption.
Step-by-step explanation:
To apply a Picture with Caption layout to a selected slide in a presentation software such as Microsoft PowerPoint, you should choose the Picture with Caption layout option. This layout allows you to insert a large image on the slide and provides a space for a caption underneath or beside the image. Layouts like Title Slide, Title and Content, and Blank Slide are suited for different types of slide content and would not be appropriate if you specifically want a layout designed to showcase a picture with a descriptive caption.