Final answer:
A rare genetic defect can lead to obesity when a person has reduced leptin levels in their body, resulting in increased hunger and decreased fat metabolism.
Step-by-step explanation:
A rare genetic defect can lead to obesity when a person has reduced leptin levels in their body. Leptin is a hormone produced by adipose tissues that regulates the balance between food intake and energy expenditure. When there is a deficiency of leptin, it can result in increased hunger and decreased fat metabolism, leading to weight gain and fatigue.