Final answer:
True, high-level programming instructions must be translated into binary instructions for the CPU to execute them.
Step-by-step explanation:
The statement is true. High-level programming instructions must indeed be translated into binary instructions, known as machine code, before they can be executed by a Central Processing Unit (CPU). When you write a program using a high-level language such as Python or Java, this code cannot be directly understood by the CPU. Therefore, it requires a translation process which is typically done through a compiler or an interpreter, each serving the purpose of converting high-level code into machine language that the CPU can understand and execute.