Final answer:
A liver lobule is a structural unit of the liver consisting of hepatocytes arranged around a central vein. The arrangements of the central vein, sinusoids, and portal triad allow for efficient nutrient exchange, oxygenation of the blood, and bile secretion.
Step-by-step explanation:
A liver lobule is a structural unit of the liver consisting of hepatocytes arranged around a central vein. The hepatocytes in a lobule are in direct contact with hepatic sinusoids, which are porous blood spaces. The functional significance of the arrangements in a liver lobule is that it allows for efficient nutrient exchange between the blood and hepatocytes through the sinusoids, oxygenation of the blood through the central vein, and the secretion of bile through the portal triad.