Question

_________ generate single stranded segments of 23 nt from miRNA that was originally dsRNA 2º conformation.

A) RNA splicing
B) RNA editing
C) RNA interference (RNAi)
D) RNA polymerization

Answer 1

RNA interference (RNAi) is the process that generates 23 nt single-stranded segments from double-stranded miRNA by cleaving it with the DICER enzyme and incorporating it into RISC.

Step-by-step explanation:

The process that generates single-stranded segments of 23 nucleotides (nt) from microRNA (miRNA) that was originally in a double-stranded RNA (dsRNA) secondary conformation is RNA interference (RNAi). RNAi involves the binding of dsRNA such as siRNAs or miRNAs to the enzyme DICER, which cleaves the RNA into short molecules of approximately 20 nucleotides in length. In this process, only one strand of the miRNA is incorporated into the RNA-induced silencing complex (RISC) to regulate gene expression by binding to mRNA and inhibiting translation or causing mRNA degradation if the miRNA is completely complementary.