Final answer:
Gout is caused by a lack in negative feedback in purine metabolism which leads to overproduction of uric acid. Primary gout involves an overactive enzyme leading to excess purines, while secondary can be due to kidney issues or other factors increasing uric acid.
Step-by-step explanation:
The disease gout is associated with a lack in negative feedback in purine metabolism. The overproduction of purines and uric acid is at the heart of primary gout, where the enzyme 'PRPP synthetase' shows altered kinetics, leading to overproduction of PRPP and the consequent overproduction of purines. In secondary gout, the disease may be caused by excess catabolism of purine or decreased excretion of uric acid due to renal failure.
Conditions like excessive tissue destruction and high non-vegetarian diets can also lead to increased levels of uric acid in the blood, contributing to gout. Foods containing nitrogenous bases, such as meat or certain beverages like tea, coffee, and chocolate, can exacerbate gout and should be avoided by those who are affected.