Final answer:
The tumor suppressor gene that is mutated in at least half of all human tumors is TP53. This gene helps control cell cycle regulation and can trigger apoptosis when necessary. Mutations in the TP53 gene are linked to numerous human cancers.
Step-by-step explanation:
Tumor Suppressor Gene Mutation in Human Tumors .Among the options provided, the tumor suppressor gene found to be mutated in at least half of all human tumors is TP53. Mutations in the gene for the P53 protein, commonly called TP53 in humans, are associated with a broad range of human cancers such as pancreatic, lung, renal cell, and breast cancer. The TP53 gene plays a critical role in cell cycle regulation at the G1 checkpoint, activating other genes that either halt the cell cycle to allow time for DNA repair or initiate cell death (apoptosis) when DNA damage can't be repaired. A mutated TP53 gene leads to unregulated cell proliferation and prevents apoptosis, thereby contributing to cancer development.