Question

Which of the following is true regarding transition state analogs?

a) They are competitive inhibitors
b) They bind to an active site with much higher affinity than most inhibitors
c) They are much more stable than the transition state
d) Their affinity for an enzyme is often much greater than the substrate

Answer 1

Transition state analogs are molecules that resemble the transition state of a reaction. They bind to the active site of an enzyme with higher affinity than most inhibitors and have a greater affinity for the enzyme than the substrate.

Step-by-step explanation:

Transition state analogs are molecules that closely resemble the transition state of a chemical reaction. They bind to the active site of an enzyme with higher affinity than most inhibitors because they mimic the transition state and form more stable interactions. Their affinity for an enzyme is often much greater than the substrate because they are designed to fit specifically into the active site and inhibit the enzymatic reaction.