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A plot of the binding of oxygen to myoglobin as a function of pO2 gives a _____ shape; a similar plot for hemoglobin gives a _____ shape.

a) Hyperbolic; hyperbolic
b) Sigmoidal; hyperbolic
c) Hyperbolic; sigmoidal
d) Sigmoidal; sigmoidal

User Jemimah
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1 Answer

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Final answer:

The binding of oxygen to myoglobin gives a hyperbolic shaped curve, while hemoglobin's oxygen-binding curve is sigmoidal due to its cooperative binding behavior. Therefore, correct option is c.

Step-by-step explanation:

A plot of the binding of oxygen to myoglobin as a function of pO2 gives a hyperbolic shape; a similar plot for hemoglobin gives a sigmoidal shape. This difference is due to the binding properties and cooperative behavior of the proteins.

Myoglobin's oxygen-binding curve is a simple equilibrium between deoxy- and oxymyoglobin and is mathematically described as hyperbolic, suggesting that myoglobin has a high affinity for oxygen across a range of oxygen pressures. Hemoglobin, however, exhibits a more complex behavior known as cooperativity.

This means that the binding of each subsequent oxygen molecule to hemoglobin affects the affinity of the remaining sites available for oxygen, resulting in a sigmoidal, or S-shaped, curve on the graph.

The initial binding of oxygen results in a low affinity, which increases as more oxygen molecules bind until it reaches a point where the hemoglobin is nearly saturated, and then the affinity decreases for the final binding sites.

User Lyes BEN
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