Final answer:
The best nursing diagnosis for a psoriasis patient feeling rejected is social isolation related to decreased activities due to fear of rejection, focusing on both social and psychological impacts of the condition.
Step-by-step explanation:
The most fitting nursing diagnosis for a patient with psoriasis who has quit a job due to feelings of being disgusting to others is D. social isolation r/t decreased activities secondary to fear of rejection.
This diagnosis specifically addresses the social aspect and the patient's self-imposed isolation due to anticipated negative evaluation by others, which aligns closely with the concept of stigmatization of illness discussed by sociologist Erving Goffman. It acknowledges the psychological and social consequences of psoriasis, apart from just the physical symptoms.