Question

Based on the information in the Table below, which medication udergoes NET secretion by the kidney? CHECK ALL THAT APPLY Assume GFR = 100 ml/min Parameter Drug A Drug B Drug C Total Clearance (L/hr) 4.8 2.7 1.4 fex 0.6 0.85 0.90 Plasma Protein Binding (%) 40 70 90 Question 5 options: Drug B Drug C Drug A

Answer 1

Drug A is the medication that undergoes net secretion by the kidney, as its clearance rate of 80 ml/min is less than the GFR of 100 ml/min, which indicates active secretion in addition to filtration.

Step-by-step explanation:

Considering that the assumed glomerular filtration rate (GFR) is 100 ml/min, the drug that undergoes net secretion by the kidney can be determined by comparing the total clearance of the drug with the GFR. If the drug's total clearance exceeds the GFR, it suggests that the drug undergoes net secretion since it is being cleared from the plasma at a rate faster than it would be by filtration alone.

According to the data provided, Drug A has a total clearance of 4.8 L/hr which is equivalent to 80 ml/min (since 1 L/hr is equal to 16.67 ml/min). Drug B has a total clearance of 2.7 L/hr, equivalent to 45 ml/min. Drug C's total clearance is 1.4 L/hr, which is equivalent to 23.33 ml/min. Therefore, Drug A is the only drug with a clearance rate higher than the given GFR of 100 ml/min, which indicates that Drug A undergoes net secretion by the kidneys.